Huntington's disease and antioxidant defence
Dithiol-based compounds maintain expression of antioxidant protein peroxiredoxin 1 that counteracts toxicity of mutant huntingtin
A Pitts, K Dailey, JT Newington, A Chien, R Arseneault, T Cann, ...
Journal of Biological Chemistry 287 (27), 22717-22729 (2012).
Protein disulfide bond formation in the cytoplasm during oxidative stress
RC Cumming, NL Andon, PA Haynes, M Park, WH Fischer, D Schubert
Journal of Biological Chemistry 279 (21), 21749-21758 (2004).
Longevity genes and metabolism
p66Shc activation promotes increased oxidative phosphorylation and renders CNS cells more vulnerable to amyloid beta toxicity.
A Lone, RA Harris, O Singh, DH Betts, RC Cumming
Sci. Rep. 8(1):17081 (2018)