Alzheimer's disease and brain metabolism

​Aerobic glycolysis is required for spatial memory acquisition but not memory retrieval in mice. Harris RC, Lone A, Lim H, Martinez F, Frame AK, Scholl TJ, Cumming RC. eNeuro. 6(1). pii: ENEURO.0389-18 (2019)

Aerobic glycolysis in the frontal cortex correlates with memory performance in wild-type mice but not the APP/PS1 mouse model of cerebral amyloidosis.  Harris RA, Tindale L, Lone A, Singh O, Macauley SL, Stanley M, Holtzman DM, Bartha R, and Cumming RC.  Journal of Neuroscience 36(6), 1871-1878 (2016).

Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease
RA Harris, L Tindale, RC Cumming
Biogerontology 15 (6), 559-577 (2014).

Reevaluating metabolism in Alzheimer's disease from the perspective of the astrocyte-neuron lactate shuttle model
JT Newington, RA Harris, RC Cumming
Journal of Neurodegenerative Diseases (2013)

​Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production
JT Newington, T Rappon, S Albers, DY Wong, RJ Rylett, RC Cumming
Journal of Biological Chemistry 287 (44), 37245-37258 (2012).

Beta-amyloid resistance and the Warburg effect: New insight into Alzheimer's disease from old metabolic pathways
J Newington, T Rujimethabas, R Cumming
Alzheimer's & Dementia 8 (4), P306 (2012).

Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect
JT Newington, A Pitts, A Chien, R Arseneault, D Schubert, RC Cumming
PLoS One 6 (4), e19191 (2011).

​The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide
T Soucek, R Cumming, R Dargusch, P Maher, D Schubert
Neuron 39 (1), 43-56 (2003).

Huntington's disease and antioxidant defence

Dithiol-based compounds maintain expression of antioxidant protein peroxiredoxin 1 that counteracts toxicity of mutant huntingtin
A Pitts, K Dailey, JT Newington, A Chien, R Arseneault, T Cann, ...
Journal of Biological Chemistry 287 (27), 22717-22729 (2012).

Protein disulfide bond formation in the cytoplasm during oxidative stress
RC Cumming, NL Andon, PA Haynes, M Park, WH Fischer, D Schubert
Journal of Biological Chemistry 279 (21), 21749-21758 (2004).
​

Longevity genes and metabolism

p66Shc activation promotes increased oxidative phosphorylation and renders CNS cells more vulnerable to amyloid beta toxicity.
 A Lone, RA Harris, O Singh, DH Betts, RC Cumming
 Sci. Rep. 8(1):17081 (2018)