Alzheimer's disease and brain metabolism

​Aerobic glycolysis in the frontal cortex correlates with memory performance in wild-type mice but not the APP/PS1 mouse model of cerebral amyloidosis.  Harris RA, Tindale L, Lone A, Singh O, Macauley SL, Stanley M, Holtzman DM, Bartha R, and Cumming RC.  Journal of Neuroscience 36(6), 1871-1878 (2016).

Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease
RA Harris, L Tindale, RC Cumming
Biogerontology 15 (6), 559-577 (2014).

Reevaluating metabolism in Alzheimer's disease from the perspective of the astrocyte-neuron lactate shuttle model
JT Newington, RA Harris, RC Cumming
Journal of Neurodegenerative Diseases (2013)

​Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production
JT Newington, T Rappon, S Albers, DY Wong, RJ Rylett, RC Cumming
Journal of Biological Chemistry 287 (44), 37245-37258 (2012).

Beta-amyloid resistance and the Warburg effect: New insight into Alzheimer's disease from old metabolic pathways
J Newington, T Rujimethabas, R Cumming
Alzheimer's & Dementia 8 (4), P306 (2012).

Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect
JT Newington, A Pitts, A Chien, R Arseneault, D Schubert, RC Cumming
PLoS One 6 (4), e19191 (2011).

​The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide
T Soucek, R Cumming, R Dargusch, P Maher, D Schubert
Neuron 39 (1), 43-56 (2003).

Huntington's disease and antioxidant defence

Dithiol-based compounds maintain expression of antioxidant protein peroxiredoxin 1 that counteracts toxicity of mutant huntingtin
A Pitts, K Dailey, JT Newington, A Chien, R Arseneault, T Cann, ...
Journal of Biological Chemistry 287 (27), 22717-22729 (2012).

Protein disulfide bond formation in the cytoplasm during oxidative stress
RC Cumming, NL Andon, PA Haynes, M Park, WH Fischer, D Schubert
Journal of Biological Chemistry 279 (21), 21749-21758 (2004).
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Longevity genes and metabolism

p66Shc activation promotes increased oxidative phosphorylation and renders CNS cells more vulnerable to amyloid beta toxicity.
 A Lone, RA Harris, O Singh, DH Betts, RC Cumming
 Sci. Rep. 8(1):17081 (2018)