The Cumming Laboratory, led by Professor Robert C. Cumming, is located in the Department of Biology at Western University in London, Ontario, Canada.
We study the changes in brain metabolism and antioxidant defence that occur with age. We are trying to understand how age-dependent alterations in metabolic and antioxidant enzyme activities contribute to neurodegenerative disorders, including Alzheimer’s disease and Huntington’s disease. In addition, we are examining the effect of experimentally manipulated metabolism on stem cell differentiation and reprogramming of somatic cells to induced pluripotent stem cells.
The urea cycle in astrocytes plays a key role in neuroinflammation, synaptic transmission, and amyloid turnover. Congratulations to PhD student Ariel Frame on an excellent commentary highlighting this novel finding in the journal Cell Metabolism.