The Cumming Laboratory, led by Professor Robert C. Cumming, is located in the Department of Biology at Western University in London, Ontario, Canada.
We study the changes in brain metabolism and antioxidant defence that occur with age. We are trying to understand how age-dependent alterations in metabolic and antioxidant enzyme activities contribute to neurodegenerative disorders, including Alzheimer’s disease and Huntington’s disease. In addition, we are examining the effect of experimentally manipulated metabolism on stem cell differentiation, both in vitro and in vivo, and reprogramming of somatic cells to induced pluripotent stem cells.
Congratulations to PhD student Andrew Powell on his recent article "Deletion of p66Shc dysregulates ERK and STAT3 activity in embryonic stem cells, enhancing their naïve-like self-renewal in the presence of LIF" published in the journal Stem Cells & Development